Mike Comrie played college hockey for the University of Michigan from 1998 to 2000. In his sophomore season, he led the Wolverines in scoring with 59 points on 24 goals and 35 assists in 40 games. For his outstanding play, Comrie was named to the CCHA First All-Star Team, a Second-Team All-American, and a top-ten finalist for the Hobey Baker Memorial Award in 2000.

Comrie went on to play 10 seasons in the NHL for six different teams: the Edmonton Oilers, Philadelphia Flyers, Phoenix Coyotes, Ottawa Senators, New York Islanders, and Pittsburgh Penguins. He was drafted by the Oilers in 1999 and became a fan favorite in his hometown. He had his most productive offensive seasons with the Oilers and Coyotes, scoring 60 points in both the 2001-02 and 2005-06 seasons. Comrie finished his career with 365 points in 589 NHL games. He retired in 2012 due to a hip injury.